期刊
CIRCULATION RESEARCH
卷 116, 期 4, 页码 633-641出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.116.304564
关键词
blood circulation; cell fusion; cell transdifferentiation; parabiosis; regeneration; stem cells
资金
- National Science Council [100-2314-B-006-046, 102-2321-B-006-027]
- National Health Research Institutes [EX10123SI]
- National Research Program for Biopharmaceuticals [NRPB100CV021, 102TM1055]
- Academia Sinica Translational Medicine Program
Rationale: The contribution of bone marrow-borne hematopoietic cells to the ischemic myocardium has been documented. However, a pivotal study reported no evidence of myocardial regeneration from hematopoietic-derived cells. The study did not take into account the possible effect of early injury-induced signaling as the test mice were parabiotically paired to partners immediately after surgery-induced myocardial injury when cross-circulation has not yet developed. Objective: To re-evaluate the role of circulating cells in the injured myocardium. Methods and Results: By combining pulse-chase labeling and parabiosis model, we show that circulating cells derived from the parabiont expressed cardiac-specific markers in the injured myocardium. Genetic fate mapping also revealed that circulating hematopoietic cells acquired cardiac cell fate by means of cell fusion and transdifferentiation. Conclusions: These results suggest that circulating cells participate in cardiomyocyte regeneration in a mouse model of parabiosis when the circulatory system is fully developed before surgery-induced heart injury.
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