期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 44, 期 2, 页码 355-373出版社
IOS PRESS
DOI: 10.3233/JAD-141884
关键词
Alzheimer's disease; causes of death; dementia; pulse; vascular aging
资金
- Sir Zelman Cowen Universities Fund
This review traces evidence that age-related dementia (Alzheimer's disease) results from the destructive impact of the pulse on cerebral vasculature. Evidence is reviewed that the neuropathology of the dementia is caused by the breakdown of small cerebral vessels (silent microbleeds), that the microbleeds result from pulse-induced damage to the cerebral vessels, and that pulse becomes increasingly destructive with age, because of the age-related stiffening of the aorta and great arteries, which causes an increase in the intensity of the pressure pulse. Implications for therapy are discussed, and evidence is reviewed that pulse-induced destruction of the brain, and of another highly vascular organ, the kidney, are becoming the default forms of death, the way we die if we survive the infections, cardiovascular disease, and malignancies, which still, for a decreasing minority, inflict the tragedy of early death.
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