期刊
BIOMEDICINES
卷 3, 期 1, 页码 1-31出版社
MDPI AG
DOI: 10.3390/biomedicines3010001
关键词
signaling pathways; tyrosine kinase receptor; protein-protein interaction; SH2 domain; post translational modification; signal transduction
The hepatocyte growth factor also known as scatter factor, is a multifunctional cytokine with the peculiar ability of simultaneously triggering epithelial cell proliferation, movement and survival. The combination of those proprieties results in the induction of an epithelial to mesenchymal transition in target cells, fundamental for embryogenesis but also exploited by tumor cells during metastatization. The hepatocyte growth factor receptor, MET, is a proto-oncogene and a prototypical transmembrane tyrosine kinase receptor. Inhere we discuss the MET molecular structure and the hepatocyte growth factor driven physiological signaling which coordinates epithelial proliferation, motility and morphogenesis.
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