期刊
HUMAN MOLECULAR GENETICS
卷 27, 期 6, 页码 1039-1054出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddy023
关键词
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资金
- National Health Research Institutes, Miaoli, Taiwan [NHRI-EX103-10316NC]
- National Taiwan University, Taipei, Taiwan [102C101-42, 103C101-C1, 104C101-B1, 105R3701]
- National Taiwan University Hospital [NTHU-UN104-018, NTUH-UN105-014, NTUH-UN106-011]
- Foundation for the Advancement of Outstanding Scholarship, Taipei, Taiwan
Visual system development is light-experience dependent, which strongly implicates epigenetic mechanisms in light-regulated maturation. Among many epigenetic processes, genomic imprinting is an epigenetic mechanism through which monoallelic gene expression occurs in a parent-of-origin-specific manner. It is unknown if genomic imprinting contributes to visual system development. We profiled the transcriptome and imprintome during critical periods of mouse visual system development under normal- and dark-rearing conditions using B6/CAST F1 hybrid mice. We identified experience-regulated, isoform-specific and brain-region-specific imprinted genes. We also found imprinted microRNAs were predominantly clustered into the Dlk1-Dio3 imprinted locus with light experience affecting some imprinted miRNA expression. Our findings provide the first comprehensive analysis of light-experience regulation of the transcriptome and imprintome during critical periods of visual system development. Our results may contribute to therapeutic strategies for visual impairments and circadian rhythm disorders resulting from a dysfunctional imprintome.
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