期刊
HUMAN IMMUNOLOGY
卷 79, 期 3, 页码 178-187出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2018.01.003
关键词
SSc; Epigenetics; Fibrosis; Immune abnormality; Vascular injury
类别
资金
- Research Deputy of Tehran University of Medical Sciences [94-01-41-28875]
The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outcomes. Three epigenetic regulatory mechanisms modulate the manifestation of a gene, namely DNA methylation, his tone changes, and microRNAs. Both epigenetics and genetics have been implicated in the pathogenesis of systemic sclerosis (SSc) disease. Genetic inheritance rate of SSc is low and the concordance rate in both mono zygotic (MZ) and dizygotic (DZ) twins is little, implying other possible pathways in SSc pathogenesis scenario. Here, we provide an extensive overview of the studies regarding different epigenetic events which may offer insights into the pathology of SSc. Furthermore, epigenetic-based interventions to treat SSc patients were discussed.
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