期刊
HUMAN IMMUNOLOGY
卷 80, 期 1, 页码 85-89出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2018.05.007
关键词
Sarcoidosis; Immunopathogenesis; Mechanism; Phenotype; MHC; HLA
类别
Sarcoidosis is a multisystem granulomatous disease of unknown cause. Evidence supports an integral role for interactions at the MHC binding site in the development of sarcoidosis. However, despite this evidence, there are clinical data that suggest that additional mechanisms are involved in the immunopathogenesis of this disease. This manuscript provides a brief clinical description of sarcoidosis, and a clinician's perspective of the immunopathogenesis of sarcoidosis in terms of the MHC binding site, MHC functional elements beyond the binding site, and other possible alternative mechanisms. Input from clinicians will be essential in establishing the immunologic cause of sarcoidosis as a detailed phenotypic characterization of disease will be required.
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