期刊
HUMAN BRAIN MAPPING
卷 39, 期 7, 页码 3005-3017出版社
WILEY
DOI: 10.1002/hbm.24056
关键词
Alzheimer's disease; dementia; diffusion MRI; grey matter; neurite orientation dispersion and density imaging; neurodegenerative disorders
资金
- Alzheimer's Research UK [ARUK-PG2014-1946]
- Alzheimer's Research UK Senior Research Fellowship
- Alzheimer's Society [AS-PG-15-025]
- ARUK [ARUK-PG2014-1946, ARUK-Network 2012-6-ICE]
- Brain Research Trust
- China Scholarship Council
- EPSRC [EP/H046410/1, EP/J020990/1, EP/K005278, EP/L022680/1, EP/M006093/1]
- ESRC/NIHR [ES/L001810/1]
- EU-FP7 project VPH-DARE@IT [FP7-ICT-2011-9-601055]
- European Union's Horizon 2020 Research and Innovation Programme [666992]
- MRC [CSUB19166, MR/J01107X/1, MR/M023664/1]
- National Institute for Health Research University College London Hospitals Biomedical Research Centre, NIHR BRC UCLH/UCL High Impact Initiative [BW.mn.BRC10269]
- NIHR Biomedical Research Unit (Dementia) at UCL
- NIHR Queen Square Dementia Biomedical Research Unit
- NIHR UCLH Biomedical Research Centre
- Wolfson Foundation
- UCL Leonard Wolfson Experimental Neurology Centre [PR/ylr/18575]
- Wellcome Trust Clinical Research Fellowship [200109/Z/15/Z]
- ESRC [ES/L001810/1] Funding Source: UKRI
- MRC [G0401247, G0601846, UKDRI-1001, MR/M009106/1, G0801306, G116/143] Funding Source: UKRI
- Alzheimers Research UK [ARUK-SRF2013-8] Funding Source: researchfish
- Economic and Social Research Council [ES/L001810/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/J020990/1, EP/H046410/1, EP/L022680/1, EP/M006093/1] Funding Source: researchfish
- Medical Research Council [MR/J01107X/1, MR/M023664/1] Funding Source: researchfish
Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion and density imaging (NODDI) is a multi-shell diffusion MRI technique that estimates neuritic microstructure in the form of orientation dispersion and neurite density indices (ODI/NDI). Mean values for cortical thickness, ODI, and NDI were extracted from predefined regions of interest in the cortical grey matter of 38 patients with young onset AD and 22 healthy controls. Five cortical regions associated with early atrophy in AD (entorhinal cortex, inferior temporal gyrus, middle temporal gyrus, fusiform gyrus, and precuneus) and one region relatively spared from atrophy in AD (precentral gyrus) were investigated. ODI, NDI, and cortical thickness values were compared between controls and patients for each region, and their associations with MMSE score were assessed. NDI values of all regions were significantly lower in patients. Cortical thickness measurements were significantly lower in patients in regions associated with early atrophy in AD, but not in the precentral gyrus. Decreased ODI was evident in patients in the inferior and middle temporal gyri, fusiform gyrus, and precuneus. The majority of AD-related decreases in cortical ODI and NDI persisted following adjustment for cortical thickness, as well as each other. There was evidence in the patient group that cortical NDI was associated with MMSE performance. These data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning.
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