期刊
HORMONE RESEARCH IN PAEDIATRICS
卷 89, 期 5, 页码 284-291出版社
KARGER
DOI: 10.1159/000486036
关键词
Adrenal glands; Androgen; Adrenarche; 21-Hydroxylase deficiency; 11-Hydroxylase
资金
- Claude D. Pepper Older Americans Independence Centers/MICHR [1K08DK109116, AG-024824/UL1TR000433]
- [R01GM086596]
The 11-oxyandrogens, particularly 11-ketotestosterone, have been recognized as a biologically important gonadal androgen in teleost (bony) fishes for decades, and their presence in human beings has been known but poorly understood. Today, we recognize that 11-oxyandrogens derive from the human adrenal glands and are major bioactive androgens, particularly in women and children. This article will review their biosynthesis and metabolism, abundance in normal and pathologic states, and potential as biomarkers of adrenal developmental changes and disease. Specifically, 11-oxyandrogens are the dominant active androgens in many patients with 21-hydroxylase deficiency. (C) 2018 S. Karger AG, Basel
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