期刊
HORMONE RESEARCH IN PAEDIATRICS
卷 90, 期 1, 页码 28-38出版社
KARGER
DOI: 10.1159/000490114
关键词
Pre-pregnancy obesity; Infancy; Insulin; IGF-I; Appetite hormones
资金
- Directorate for Food, Fisheries and Agri Business, project Complementary and young child feeding (CYCF) - impact on short and long term development and health.
- Aase and Ejnar Danielsens Foundation
- Augustinus Foundation
- University of Copenhagen Excellence Program for Interdisciplinary
- Medical Research Council [MC_UU_12015/2]
- MRC [MC_UU_12015/2] Funding Source: UKRI
Background/Aims: Exposure to obesity during pregnancy may lead to adverse changes in the offspring's metabolic profile. We compared appetite - and growth-related hormones in a cohort of infants born to obese mothers (SKOT-II) with infants born mainly to nonobese mothers (SKOT-I). Methods: Infants from SKOT-I (n = 273) and SKOT-II (n = 132) were examined including anthropometric measurements and blood samples analyzed for glucose, insulin, insulin-like growth factor-I (IGF-I), adiponectin, and leptin. Information on breastfeeding and parental characteristics were also collected. Results: At 9 months of age, SKOT-II infants were 3.6% heavier and 1.2% longer than SKOT-I infants even though their mothers were shorter. There was no difference in body mass index (BMI). SKOT-II infants had higher levels of insulin, adiponectin, and leptin but lower levels of IGF-I compared to SKOT-I infants (all p = 0.015). These differences remained, except for leptin, when adjusted for current weight. Breastfeeding versus nonbreastfeeding at 9 months was associated with lower concentrations of all hormones (all p = 0.003). In adjusted models, maternal BMI at 9 months was positively associated with insulin and adiponectin and negatively with IGF-I. Conclusions: Pre-pregnancy obesity confers symmetrically larger infant body size and higher levels of most growth - and appetite-related hormones but surprisingly lower levels of IGF-I, suggesting other possible infant growth-promoting effects through insulin. (C) 2018 S. Karger AG, Basel
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