期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 45, 期 2, 页码 376-394出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-013-1905-9
关键词
Eyeblink conditioning; Neurodevelopmental disorders; Autism spectrum disorder; Associative learning; Cerebellum
资金
- NIMH NIH HHS [MH 080759] Funding Source: Medline
Eyeblink conditioning (EBC) is a classical conditioning paradigm typically used to study the underlying neural processes of learning and memory. EBC has a well-defined neural circuitry, is non-invasive, and can be employed in human infants shortly after birth making it an ideal tool to use in both developing and special populations. In addition, abnormalities in the cerebellum, a region of the brain highly involved in EBC, have been implicated in a number of neurodevelopmental disorders including autism spectrum disorders (ASDs). In the current paper, we review studies that have employed EBC as a biomarker for several neurodevelopmental disorders including fetal alcohol syndrome, Down syndrome, fragile X syndrome, attention deficit/hyperactivity disorder, dyslexia, specific language impairment, and schizophrenia. In addition, we discuss the benefits of using such a tool in individuals with ASD.
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