期刊
HETEROCYCLIC COMMUNICATIONS
卷 24, 期 4, 页码 219-230出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/hc-2018-0099
关键词
antibacterial activity; aryl disulfide; diaryl sulfide; dibenzothiazepine; L-cysteine; one-pot; S-arylation; SNAr reaction; sulfur-containing heterocycle
Dibenzothiazepine analogues containing lactam, amidine and imine moieties were prepared from 2-aminophenyl disulfides via one-pot S-arylation. The S-arylation involved cleavage of an S-S bond of disulfides and SNAr reaction in aqueous ammonia solution of L-cysteine to afford diaryl sulfides. Dibenzothiazepine analogues having lactam and amidine moieties were obtained by cyclization of the corresponding diaryl sulfides under acidic conditions. One-pot S-arylation of 2-bromo-5-nitrobenzaldehyde gave dibenzothiazepine analogues with an imine moiety in one step through intramolecular cyclization. Compounds with antibacterial activities against Staphylococcus aureus and Escherichia coli were obtained.
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