期刊
PEDIATRIC OBESITY
卷 10, 期 1, 页码 23-29出版社
WILEY
DOI: 10.1111/j.2047-6310.2014.221.x
关键词
Biomarker; breath testing; insulin resistance; oxidative stress
类别
资金
- Ohio Department of Development [BRCP 08-049]
- National Institutes of Health (NIH) [HL107147, HL081064, HL103453, HL109250, RR026231]
ObjectiveThe objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. Study designSingle exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS). ResultsSixty overweight/obese children and 55 lean controls were included. Compared with the lean group, the obese group was significantly older (14.12.8 vs. 12.1 +/- 3.0 years), taller (164.8 +/- 10.9 vs. 153.3 +/- 17.1cm) and more likely to be Caucasian (60% vs. 35.2%); P<0.05 for all. A comparison of the SIFT-MS results of the obese group with the lean group revealed differences in concentration of more than 50 compounds. A panel of four VOCs can identify the presence of overweight/obesity with excellent accuracy. Further analysis revealed that breath isoprene, 1-decene, 1-octene, ammonia and hydrogen sulfide were significantly higher in the obese group compared with the lean group (P value<0.01 for all). ConclusionObese children have a unique pattern of exhaled VOCs. Changes in VOCs observed in this study may help to gain insight into pathophysiological processes and pathways leading to the development of childhood obesity.
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