期刊
HEARING RESEARCH
卷 368, 期 -, 页码 86-91出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.heares.2018.03.003
关键词
Acute sensorineural hearing loss; JNK pathway; D-JNKI-1; AM-111; Brimapitide; Noise trauma
There is a growing interest in the auditory community to develop novel prophylactic and therapeutic drugs to prevent permanent sensorineural hearing loss following acute cochlear injury. The jun-N-terminal protein kinase (JNK) pathway plays a crucial role in acute sensory hearing loss. Blocking the JNK pathway using the cell-penetrating peptide D-JNKI-1 (AM-111/brimapitide) has shown promise as both a prophylactic and therapeutic agent for acute cochlear injury. A number of pre-clinical and clinical studies have determined the impact of D-JNKI-1 on acute sensorineural hearing loss. Given the inner-ear selective therapeutic profile, local route of administration, and ability to diffuse across cellular membranes rapidly using both active and passive transport makes D-JNK-1 a promising oto-protective drug. In this review article, we discuss the application of D-JNKI-1 in various auditory disorders as well as its pharmacological properties and distribution in the cochlea. (C) 2018 Elsevier B.V. All rights reserved.
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