期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 40, 期 8, 页码 1812-1823出版社
WILEY
DOI: 10.1002/hed.25165
关键词
molecular marker tests; noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); thyroid cancer; thyroid nodule; thyroid surgery
资金
- NCI NIH HHS [P30 CA076292] Funding Source: Medline
BackgroundThe impact of oncogene panel results on the surgical management of indeterminate thyroid nodules (ITNs) is currently unknown. MethodsSurgical management of 649 patients consecutively evaluated from October 2008 to April 2016 with a single nodule biopsied and indeterminate cytology (193 evaluated with and 456 without oncogene panels) was assessed and compared. Histological features of 629 consecutively resected ITNs (164 evaluated with and 465 without oncogene panels) were also characterized and compared. ResultsOncogene panel evaluation was associated with higher rates of total thyroidectomy (45% vs 28%; P = .006), and central lymph node dissection (19% vs 12%; P = .03) without increasing the yield of malignancy or decreasing the rate of completion thyroidectomy. Most malignancies (64%), including 83% of those with driver mutation identified, were low-risk cancers for which a lobectomy could have been sufficient initial treatment. ConclusionCurrent oncogene panel results seem insufficient to guide the surgical extent of solitary ITNs.
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