期刊
GYNECOLOGICAL ENDOCRINOLOGY
卷 34, 期 8, 页码 684-688出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2018.1431769
关键词
Fertility treatment; free-fatty acids; mitochondria
资金
- Japan Agency for Medical Research and Development [17gk0110014s0402]
- Japan Society for the Promotion of Science [17K08144]
- Grants-in-Aid for Scientific Research [17K08144] Funding Source: KAKEN
Age-dependent decline of mitochondrial function has been proposed to be a main cause of decline of embryo quality. Then, L-carnitine plays important roles in reducing the membranous toxicity of free-fatty acids by forming acyl-carnitine and promoting beta-oxidation, preventing cell damage. Recent research revealed that L-carnitine played important roles in vitro in oocyte growth, oocyte maturation and embryo development. However, such beneficial effects of L-carnitine in vivo have yet to be verified. The effect of oral L-carnitine supplementation on embryo quality and implantation potential was examined. A total of 214 patients were included in this study. They all previously received in vitro fertilization-embryo transfer (IVF-ET) and failed to conceive. Then they were administered L-carnitine for 82 days on average and underwent IVF-ET again. There were no significant differences in the total number of retrieved oocytes, and their maturation and fertilization rates between before and after L-carnitine administration. The quality of embryos on Days 3 and 5 after insemination was improved following L-carnitine administration (p<.05) in cycles after L-carnitine administration compared with previous cycles. Healthy neonates were born after IVF-ET following L-carnitine administration. Our data suggested that oral administration of L-carnitine to fertility patients improved the developmental competence of their oocytes after insemination.
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