期刊
GUT AND LIVER
卷 12, 期 4, 页码 402-410出版社
EDITORIAL OFFICE GUT & LIVER
DOI: 10.5009/gnl17414
关键词
Survival; Endoscopic mucosal dissection; Stomach neoplasms
资金
- National Evidence-based Healthcare Collaborating Agency (NECA) in Korea [NA2010-001]
- National Evidence-based Healthcare Collaborating Agency (NECA) [NA 16-001]
Background/Aims: Endoscopic submucosa I dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3% of the cases, and curative resection was achieved in 86.1%. During the 5-year follow-up, the overall survival rate was 96.6%, and the disease specific free survival rate was 90.6%. Local recurrence developed in 0.9%, and metachronous tumor development occurred in 7.8%; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5% during-follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies.
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