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N. Garg et al.
ONCOGENE (2017)
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
Farhad Seif et al.
CELL COMMUNICATION AND SIGNALING (2017)
Mitochondrial STAT3: Powering up a potent factor
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CYTOKINE (2016)
Mitochondrial Stat3, the Need for Design Thinking
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INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2016)
Control of glioblastoma tumorigenesis by feed-forward cytokine signaling
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NATURE NEUROSCIENCE (2016)
A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3
Daniel J. Garama et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis
Beatrice Grabner et al.
NATURE COMMUNICATIONS (2015)
STAT3 regulated ARF expression suppresses prostate cancer metastasis
Jan Pencik et al.
NATURE COMMUNICATIONS (2015)
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells
Can Kucuk et al.
NATURE COMMUNICATIONS (2015)
Differential roles of STAT3 in the initiation and growth of lung cancer
J. Zhou et al.
ONCOGENE (2015)
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2
D. Zhao et al.
ONCOGENE (2015)
S-Glutathionylation at Cys328 and Cys542 Impairs STAT3 Phosphorylation
Elena Butturini et al.
ACS CHEMICAL BIOLOGY (2014)
TLR9 Is Critical for Glioma Stem Cell Maintenance and Targeting
Andreas Herrmann et al.
CANCER RESEARCH (2014)
Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis
Sutapa Ray et al.
CELLULAR SIGNALLING (2014)
Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes
Everardo Macias et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)
Signal Integration and Gene Induction by a Functionally Distinct STAT3 Phosphoform
Matthew S. Waitkus et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Toward a new STATe: The role of STATs in mitochondrial function
Jeremy A. Meier et al.
SEMINARS IN IMMUNOLOGY (2014)
S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3
Saul J. Priceman et al.
CELL REPORTS (2014)
Enhancing Chemotherapy Efficacy in Pten-Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
Alberto Toso et al.
CELL REPORTS (2014)
The Arrival of JAK Inhibitors: Advancing the Treatment of Immune and Hematologic Disorders
Yasuko Furumoto et al.
BIODRUGS (2013)
Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer
Jie Liang et al.
CANCER CELL (2013)
Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
Eunhee Kim et al.
CANCER CELL (2013)
Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells
Myriam Elschami et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2013)
The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain
Prasad Tammineni et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727
Qifang Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
G-protein-coupled Receptor Agonist BV8/Prokineticin-2 and STAT3 Protein Form a Feed-forward Loop in Both Normal and Malignant Myeloid Cells
Hong Xin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance
Shu-Chen Liu et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Therapeutic modulators of STAT signalling for human diseases
Gabriella Miklossy et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice
Gerardo G. Mackenzie et al.
PLOS ONE (2013)
The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation
Daniel J. Gough et al.
PLOS ONE (2013)
Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes
Ivan H. W. Ng et al.
BIOCHEMICAL JOURNAL (2012)
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
Andres Jerez et al.
BLOOD (2012)
Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype
Charlie Mantel et al.
BLOOD (2012)
S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites
Jiehui Deng et al.
CANCER CELL (2012)
STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation
Hazel Tye et al.
CANCER CELL (2012)
Signal Transducer and Activator of Transcription 3 (STAT3) Protein Suppresses Adenoma-to-carcinoma Transition in Apcmin/+ Mice via Regulation of Snail-1 (SNAI) Protein Stability
Jongdae Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans
Atsuo Ochi et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
Hanna L. M. Koskela et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
STAT3 negatively regulates thyroid tumorigenesis
Joana Pinto Couto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Multi-tasking: nuclear transcription factors with novel roles in the mitochondria
Karol Szczepanek et al.
TRENDS IN CELL BIOLOGY (2012)
Alkylation of Cysteine 468 in Stat3 Defines a Novel Site for Therapeutic Development
Ralf Buettner et al.
ACS CHEMICAL BIOLOGY (2011)
JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma
Katrien Van Roosbroeck et al.
BLOOD (2011)
STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis
Ryan B. Corcoran et al.
CANCER RESEARCH (2011)
Lysine methylation of promoter-bound transcription factors and relevance to cancer
George R. Stark et al.
CELL RESEARCH (2011)
Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer
Annette Eyking et al.
GASTROENTEROLOGY (2011)
p19ARF/p1ARF Controls Oncogenic Functions of Signal Transducer and Activator of Transcription 3 in Hepatocellular Carcinoma
Doris Schneller et al.
HEPATOLOGY (2011)
Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein
Michel Bernier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species
Karol Szczepanek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Increased Levels of Circulating Interleukin 6, Interleukin 8, C-Reactive Protein, and Risk of Lung Cancer
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JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2011)
TLR4 knockout protects mice from radiation-induced thymic lymphoma by downregulation of IL6 and miR-21
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LEUKEMIA (2011)
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
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NATURE (2011)
PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3
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SCIENCE SIGNALING (2011)
Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation
Guobin He et al.
CANCER CELL (2010)
Distinct Clinical Phenotypes Associated with JAK2V617F Reflect Differential STAT1 Signaling
Edwin Chen et al.
CANCER CELL (2010)
Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice
Monica Musteanu et al.
GASTROENTEROLOGY (2010)
Stoichiometry of STAT3 and Mitochondrial Proteins IMPLICATIONS FOR THE REGULATION OF OXIDATIVE PHOSPHORYLATION BY PROTEIN-PROTEIN INTERACTIONS
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
Heehyoung Lee et al.
NATURE MEDICINE (2010)
Disruption of Astrocyte STAT3 Signaling Decreases Mitochondrial Function and Increases Oxidative Stress In Vitro
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PLOS ONE (2010)
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
TGF-β Increases Glioma-Initiating Cell Self-Renewal through the Induction of LIF in Human Glioblastoma
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CANCER CELL (2009)
Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression
Jill J. Ranger et al.
CANCER RESEARCH (2009)
Stat3 Inhibition Activates Tumor Macrophages and Abrogates Glioma Growth in Mice
Leying Zhang et al.
GLIA (2009)
Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia
K. Nebral et al.
LEUKEMIA (2009)
JAK mutations in high-risk childhood acute lymphoblastic leukemia
Charles G. Mullighan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation
Daniel J. Gough et al.
SCIENCE (2009)
Function of Mitochondrial Stat3 in Cellular Respiration
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SCIENCE (2009)
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia
Michael H. Tomasson et al.
BLOOD (2008)
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11) in a patient with acute myeloid leukemia
Gabriella Cirmena et al.
CANCER GENETICS AND CYTOGENETICS (2008)
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
Nuria de la Iglesia et al.
GENES & DEVELOPMENT (2008)
Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia
Jennifer L. Poitras et al.
GENES CHROMOSOMES & CANCER (2008)
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
Elisabetta Flex et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness
Nuria de la Iglesia et al.
JOURNAL OF NEUROSCIENCE (2008)
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
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JOURNAL OF CLINICAL INVESTIGATION (2007)
Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung
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CANCER RESEARCH (2007)
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF kappa B
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GENES & DEVELOPMENT (2007)
Membrane-associated STAT3 and PY-STAT3 in the cytoplasm
M Shah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor
JV Alvarez et al.
CANCER RESEARCH (2006)
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
S Haan et al.
CELLULAR SIGNALLING (2005)
STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen
S Ray et al.
GASTROENTEROLOGY (2005)
Evaluation of potential Stat3-regulated genes in human breast cancer
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
HW Lo et al.
CANCER CELL (2005)
Reduced STAT3 activity in mice mimics clinical disease syndromes
YH Shen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
C James et al.
NATURE (2005)
A gain-of-function mutation of JAK2 in myeloproliferative disorders
R Kralovics et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
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CANCER CELL (2005)
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
ZL Yuan et al.
SCIENCE (2005)
Real time analysis of STAT3 nucleocytoplasmic shuttling
AL Pranada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Molecular dynamics of STAT3 on IL-6 signaling pathway in living cells
K Watanabe et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3
E Perry et al.
ONCOGENE (2004)
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
J Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
LX Song et al.
ONCOGENE (2003)
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
SO Rahaman et al.
ONCOGENE (2002)
Role of the leukemia-associated transcription factor STAT3 in platelet physiology
AO Vassilev et al.
LEUKEMIA & LYMPHOMA (2002)
Association of the chaperone (GRP58/ER-60/ERp57) with membrane glucose-regulated protein 58 stat3 in cytosol and plasma complexes
GG Guo et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2002)
Cytokine signaling - STATs in plasma membrane rafts
PB Sehgal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells
WM Burke et al.
ONCOGENE (2001)
STAT3 activation is required for Asp816 mutant c-Kit induced tumorigenicity
ZQ Ning et al.
ONCOGENE (2001)
Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Gαo protein
PT Ram et al.
SCIENCE (2000)
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