期刊
GREEN CHEMISTRY
卷 20, 期 6, 页码 1262-1269出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc03205f
关键词
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资金
- RWTH Aachen University - Excellence Initiative of the German federal and state governments
- EPSRC [EP/R019655/1]
- EU
- federal state of North Rhine-Westphalia [EFRE 30 00 883 02]
The oligomerisation of l-amino acids by papain was studied in a mixer ball mill and in a planetary ball mill. The biocatalyst proved stable under the ball milling conditions providing the corresponding oligopeptides in good to excellent yields and with a variable degree of polymerisation. Both parameters were found to be dependent on the reaction conditions and on the nature of the amino acid (specifically on its side-chain size and hydrophobicity). In addition, the chemoenzymatic oligomerisation was demonstrated by utilising twin-screw extrusion technology, which allowed for a scalable continuous process. Finally, the synthesised oligo(l-Leu) 2b proved to be active as a catalyst in the Julia-Colonna enantioselective epoxidation of chalcone derivatives.
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