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Epithelial-mesenchymal transition in cancer development and its clinical significance
Masaaki Iwatsuki et al.
CANCER SCIENCE (2010)
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kai Kessenbrock et al.
CELL (2010)
Rac and Rho GTPases in cancer cell motility control
Matteo Parri et al.
CELL COMMUNICATION AND SIGNALING (2010)
microRNA-451 A conditional switch controlling glioma cell proliferation and migration
Jakub Godlewski et al.
CELL CYCLE (2010)
Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate
Steven D. Rosen et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2010)
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics
Uri Barash et al.
FASEB JOURNAL (2010)
Hyaluronan Stabilizes Focal Adhesions, Filopodia, and the Proliferative Phenotype in Esophageal Squamous Carcinoma Cells
Soeren Twarock et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
Michael D. Schaller
JOURNAL OF CELL SCIENCE (2010)
Transforming growth factor-β1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-κB pathways
Hsi-Lung Hsieh et al.
JOURNAL OF NEUROINFLAMMATION (2010)
Matrix Metalloproteinase-19 is Highly Expressed in Astroglial Tumors and Promotes Invasion of Glioma Cells
Imke Lettau et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
Metzincin Proteases and Their Inhibitors: Foes or Friends in Nervous System Physiology?
Santiago Rivera et al.
JOURNAL OF NEUROSCIENCE (2010)
Heparanase expression of glioma in human and animal models Laboratory investigation
Xin Hong et al.
JOURNAL OF NEUROSURGERY (2010)
MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells
Jakub Godlewski et al.
MOLECULAR CELL (2010)
CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-beta1
Giuseppe Sciume et al.
NEURO-ONCOLOGY (2010)
The Extracellular Matrix Molecule Hyaluronic Acid Regulates Hippocampal Synaptic Plasticity by Modulating Postsynaptic L-Type Ca2+ Channels
Gaga Kochlamazashvili et al.
NEURON (2010)
KIAA0510, the 3'-untranslated region of the tenascin-R gene, and tenascin-R are overexpressed in pilocytic astrocytomas
I. El Ayachi et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2010)
Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival
Lianshu Ding et al.
TRANSLATIONAL RESEARCH (2010)
MicroRNAs: Small RNAs With Big Effects
Dany Anglicheau et al.
TRANSPLANTATION (2010)
Semaphorin signaling: molecular switches at the midline
Alwin A. H. A. Derijck et al.
TRENDS IN CELL BIOLOGY (2010)
Chemokines and chemokine receptors: new insights into cancer-related inflammation
Gwendal Lazennec et al.
TRENDS IN MOLECULAR MEDICINE (2010)
Epithelial-mesenchymal Transition and Cell Invasion
Hwajin Son et al.
TOXICOLOGICAL RESEARCH (2010)
High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas
Carole Colin et al.
ACTA NEUROPATHOLOGICA (2009)
Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B
So-Young Hwang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
From mechanotransduction to extracellular matrix gene expression in fibroblasts
Matthias Chiquet et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
Radiolabeled Cyclic RGD Peptides as Integrin αvβ3-Targeted Radiotracers: Maximizing Binding Affinity via Bivalency
Shuang Liu
BIOCONJUGATE CHEMISTRY (2009)
CXCR4 mediates the proliferation of glioblastoma progenitor cells
Moneeb Ehtesham et al.
CANCER LETTERS (2009)
Tenascin-C Is a Novel RBPJk-Induced Target Gene for Notch Signaling in Gliomas
Balasubramanian Sivasankaran et al.
CANCER RESEARCH (2009)
The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells
Theresa A. Ulrich et al.
CANCER RESEARCH (2009)
Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue
Eishu Hirata et al.
CANCER SCIENCE (2009)
Emerging roles of chemokines in prostate cancer
David Vindrieux et al.
ENDOCRINE-RELATED CANCER (2009)
Imaging Glioma Cell Invasion In Vivo Reveals Mechanisms of Dissemination and Peritumoral Angiogenesis
Frank Winkler et al.
GLIA (2009)
ROCKs Are Expressed In Brain Tumors and Are Required for Glioma-Cell Migration On Myelinated Axons
Patrick Oellers et al.
GLIA (2009)
Epigenetic Control of the Invasion-promoting MT1-MMP/MMP-2/TIMP-2 Axis in Cancer Cells
Andrei V. Chernov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The basics of epithelial-mesenchymal transition
Raghu Kalluri et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Phase II Trial of Single-Agent Bevacizumab Followed by Bevacizumab Plus Irinotecan at Tumor Progression in Recurrent Glioblastoma
Teri N. Kreisl et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
A Shared Mechanism of Adhesion Modulation for Tenascin-C and Fibulin-1
Selwyn A. Williams et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Lactate promotes glioma migration by TGF-β2-dependent regulation of matrix metalloproteinase-2
Fusun Baumann et al.
NEURO-ONCOLOGY (2009)
S-Adenosylhomocysteine increases β-amyloid formation in BV-2 microglial cells by increased expressions of β-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters
Hung-Chi Lin et al.
NEUROTOXICOLOGY (2009)
Interactions between extracellular matrix and growth factors in wound healing
Gregory S. Schultz et al.
WOUND REPAIR AND REGENERATION (2009)
The role of tenascin-C in tissue injury and tumorigenesis
Kim S. Midwood et al.
JOURNAL OF CELL COMMUNICATION AND SIGNALING (2009)
The Effect of Hyaluronic Acid on the Invasiveness of Malignant Glioma Cells : Comparison of Invasion Potential at Hyaluronic Acid Hydrogel and Matrigel
Shu-Guang Jin et al.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY (2009)
The interface between glial progenitors and gliomas
Peter Canoll et al.
ACTA NEUROPATHOLOGICA (2008)
The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma
Bodour Salhia et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
Extensive expansion and diversification of the chemokine gene family in zebrafish: Identification of a novel chemokine subfamily CX
Hisayuki Nomiyama et al.
BMC GENOMICS (2008)
Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker?
L. Karayan-Tapon et al.
BRITISH JOURNAL OF CANCER (2008)
Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression
Naoki Itano et al.
CANCER SCIENCE (2008)
The epithelial-mesenchymal transition generates cells with properties of stem cells
Sendurai A. Mani et al.
CELL (2008)
Asymmetric focal adhesion disassembly in motile cells
Joshua A. Broussard et al.
CURRENT OPINION IN CELL BIOLOGY (2008)
Robo-Slit interactions regulate longitudinal axon pathfinding in the embryonic vertebrate brain
C. A. Devine et al.
DEVELOPMENTAL BIOLOGY (2008)
Hyaluronan and hyaluronidase in genitourinary tumors
Melanie et al.
Frontiers in Bioscience-Landmark (2008)
Extracellular matrix of the central nervous system: from neglect to challenge
Dieter R. Zimmermann et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2008)
The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility
Bin Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling
William C. Lamanna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2
Youngmi Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Proteases: Multifunctional Enzymes in Life and Disease
Carlos Lopez-Otin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions?
Christopher Alan Maxwell et al.
JOURNAL OF CELL SCIENCE (2008)
Invadopodia: At the cutting edge of tumour invasion
Stanley S. Stylli et al.
JOURNAL OF CLINICAL NEUROSCIENCE (2008)
Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells
Xin Hong et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2008)
The role of myosin II in glioma invasion of the brain
Christopher Beadle et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
The crosstalk of hyaluronan-based extracellular matrix and synapses
Renato Frischknecht et al.
NEURON GLIA BIOLOGY (2008)
Tenascin-C expression relates to clinicopathological features in pilocytic and diffuse astrocytomas
C. Maris et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2008)
PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion
Sebastian Seufert et al.
PPAR RESEARCH (2008)
Role of hyaluronan in glioma invasion
Jong Bae Park et al.
CELL ADHESION & MIGRATION (2008)
Chemokines: novel targets for breast cancer metastasis
Simi Ali et al.
CANCER AND METASTASIS REVIEWS (2007)
Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761
Yingli Fu et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2007)
Integrins: Molecular determinants of glioma invasion
Giovanna M. D'Abaco et al.
JOURNAL OF CLINICAL NEUROSCIENCE (2007)
Diffuse glioma growth: a guerilla war
An Claes et al.
ACTA NEUROPATHOLOGICA (2007)
Functional atlas of the integrin adhesome
Ronen Zaidel-Bar et al.
NATURE CELL BIOLOGY (2007)
Regulation of fibroblast migration by tenascin-C
A. Trebaul et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Brain matrix: structure, turnover and necessity
U. Rauch
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
The 2007 WHO classification of tumours of the central nervous system
David N. Louis et al.
ACTA NEUROPATHOLOGICA (2007)
Slit-Robo interactions during cortical development
William D. Andrews et al.
JOURNAL OF ANATOMY (2007)
Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration
Carmen Eckerich et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
Ta-Jen Liu et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Involvement of Hif-1 in desferrioxamine-induced invasion of glioblastoma cells
Anja Elstner et al.
CLINICAL & EXPERIMENTAL METASTASIS (2007)
Molecular targets of glioma invasion
M. Nakada et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
The integrins
Yoshikazu Takada et al.
GENOME BIOLOGY (2007)
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion
David Zagzag et al.
LABORATORY INVESTIGATION (2006)
Tuning inflammation and immunity by chemokine sequestration: decoys and more
Alberto Mantovani et al.
NATURE REVIEWS IMMUNOLOGY (2006)
Aspects of the biology of hyaluronan, a largely neglected but extremely versatile molecule
Karl M. Stuhlmeier
WIENER MEDIZINISCHE WOCHENSCHRIFT (2006)
Hyaluronan induces vascular smooth muscle cell migration through RHAMM-mediated PI3K-dependent Rac activation
Yann Goueffic et al.
CARDIOVASCULAR RESEARCH (2006)
Filopodia formation via a specific Eph family member and PI3K in immortalized cholangiocytes
Koji Fukushima et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Angiogenesis-independent tumor growth mediated by stem-like cancer cells
Per O. Sakariassen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A novel one-armed anti-c-met antibody inhibits glioblastoma growth in vivo
Tobias Martens et al.
CLINICAL CANCER RESEARCH (2006)
Expression of CXC chemokine receptors 1-5 and their ligands in human glioma tissues: Role of CXCR4 and SDF1 in glioma cell proliferation and migration
Adriana Bajetto et al.
NEUROCHEMISTRY INTERNATIONAL (2006)
TGF-β and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells
Guenter Eisele et al.
BRAIN (2006)
The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer
Spyros S. Skandalis et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)
Mechanisms of angiogenesis in gliomas
O. Kargiotis et al.
JOURNAL OF NEURO-ONCOLOGY (2006)
Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas
Chlara Calatozzolo et al.
CANCER BIOLOGY & THERAPY (2006)
CD44 adhesion molecule and neuro-glial proteoglycan NG2 as invasive markers of glioma
Marzenna Wiranowska et al.
BRAIN CELL BIOLOGY (2006)
Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells
Gui Su et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Transplanted glioma cells migrate and proliferate on host brain vasculature: A dynamic analysis
A Farin et al.
GLIA (2006)
SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion
Xin Hong et al.
CANCER LETTERS (2006)
Heparanase induces vascular endothelial growth factor expression: Correlation with p38 phosphorylation levels and Src activation
A Zetser et al.
CANCER RESEARCH (2006)
Transforming growth factor-beta: A molecular target for the future therapy of glioblastoma
W Wick et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
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J Held-Feindt et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Perlecan signaling: Helping hedgehog stimulate prostate cancer growth
Surnana Datta et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)
EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase
M Parri et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
HYAL1 hyaluronidase in prostate cancer: A tumor promoter and suppressor
VB Lokeshwar et al.
CANCER RESEARCH (2005)
Novel tumor-specific isoforms of BEHAB/Brevican identified in human malignant gliomas
MS Viapiano et al.
CANCER RESEARCH (2005)
The brain within the tumor:: new roles for axon guidance molecules in cancers
A Chédotal et al.
CELL DEATH AND DIFFERENTIATION (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
The role of chemokines and extracellular matrix components in the migration of T lymphocytes into three-dimensional substrata
J Ivanoff et al.
IMMUNOLOGY (2005)
Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development
H Fujisawa
JOURNAL OF NEUROBIOLOGY (2004)
Review - Proteases, extracellular matrix, and cancer - A workshop of the path B study section
YA DeClerck et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
DJ Brat et al.
CANCER RESEARCH (2004)
RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: A different interpretation of redundancy
S Nedvetzki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Hyaluronan: From extracellular glue to pericellular cue
BP Toole
NATURE REVIEWS CANCER (2004)
Quantification of thrombospondin-1 secretion and expression of αvβ3 and α3β1 integrins and syndecan-1 as cell-surface receptors for thrombospondin-1 in malignant glioma cells
H Naganuma et al.
JOURNAL OF NEURO-ONCOLOGY (2004)
Role of synaptojanin 2 in glioma cell migration and invasion
YY Chuang et al.
CANCER RESEARCH (2004)
Membrane associated proteases and their inhibitors in tumour angiogenesis
A Noel et al.
JOURNAL OF CLINICAL PATHOLOGY (2004)
Pathology and molecular genetics of astrocytic gliomas
G Reifenberger et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2004)
Increased expression of focal adhesion kinase in thyroid cancer: Immunohistochemical study
SJ Kim et al.
JOURNAL OF KOREAN MEDICAL SCIENCE (2004)
Induction of CD44 and MMP expression by hyaluronidase treatment of articular chondrocytes
M Ohno-Nakahara et al.
JOURNAL OF BIOCHEMISTRY (2004)
Phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells
M Nakada et al.
CANCER RESEARCH (2004)
Proteases in brain tumour progression
N Levicar et al.
ACTA NEUROCHIRURGICA (2003)
Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors
EJ Franzmann et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma
MS Viapiano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Molecular mechanisms of glioma invasiveness: The role of proteases
JS Rao
NATURE REVIEWS CANCER (2003)
Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins
J Rieger et al.
GLIA (2003)
Heparanase mediates cell adhesion independent of its enzymatic activity
O Goldschmidt et al.
FASEB JOURNAL (2003)
Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells:: Direct and synergistic effects with transforming growth factor β1
I Kalembeyi et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Diffusion parameters of the extracellular space in human gliomas
L Vargová et al.
GLIA (2003)
Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44
D Murakami et al.
ONCOGENE (2003)
Transcriptional regulation of osteopontin and the metastatic phenotype: Evidence for a Ras-activated enhancer in the human OPN promoter
DT Denhardt et al.
CLINICAL & EXPERIMENTAL METASTASIS (2003)
Role of ephrin B2 in human retinal endothelial cell proliferation and migration
JJ Steinle et al.
CELLULAR SIGNALLING (2003)
CD44: From adhesion molecules to signalling regulators
H Ponta et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Neuro-glia interaction effects on GFAP gene:: a novel role for transforming growth factor-β1
TCLDE Spohr et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
Brevican isoforms associate with neural membranes
CI Seidenbecher et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Regulation of hyaluronidase activity by alternative mRNA splicing
VB Lokeshwar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Strategies for MMP inhibition in cancer:: Innovations for the post-trial era
CM Overall et al.
NATURE REVIEWS CANCER (2002)
Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165
CH Gu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Clinical impact and functional aspects of tenascin-C expression during glioma progression
C Herold-Mende et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Proteases and the biology of glioma invasion
DK Binder et al.
JOURNAL OF NEURO-ONCOLOGY (2002)
The six hyaluronidase-like genes in the human and mouse genomes
AB Csoka et al.
MATRIX BIOLOGY (2001)
Command and control: regulatory pathways controlling invasive behavior of the border cells
DJ Montell
MECHANISMS OF DEVELOPMENT (2001)
Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion
CL Hall et al.
MATRIX BIOLOGY (2001)
Heparanase as mediator of angiogenesis: mode of action
M Elkin et al.
FASEB JOURNAL (2001)
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway
H Miao et al.
NATURE CELL BIOLOGY (2001)
Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta
W Wick et al.
JOURNAL OF NEURO-ONCOLOGY (2001)
Hyaluronate receptors mediating glioma cell migration and proliferation
Y Akiyama et al.
JOURNAL OF NEURO-ONCOLOGY (2001)
Integrins and actin filaments: Reciprocal regulation of cell adhesion and signaling
DA Calderwood et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
EC Holland et al.
NATURE GENETICS (2000)
Transforming growth factors β1 (TGF-β1) and TGF-β2 promote glioma cell migration via up-regulation of αvβ3 integrin expression
M Platten et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Chemokines: A new classification system and their role in immunity
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IMMUNITY (2000)
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