4.4 Article

Identification of dementia using standard clinical assessments by primary care physicians in Japan

期刊

GERIATRICS & GERONTOLOGY INTERNATIONAL
卷 18, 期 5, 页码 738-744

出版社

WILEY
DOI: 10.1111/ggi.13243

关键词

clinical assessment; dementia; integrated discrimination improvement; Japan; receiver operating characteristic curve

资金

  1. JSPS KAKENHI from Japan Society for the Promotion of Science [26253043]
  2. Ministry of Health, Labor and Welfare, Health and Labor Sciences Research Grants, Japan [H21-Ninchisho-Wakate-007, H24-Ninchisho-Wakate-003]
  3. Grants-in-Aid for Scientific Research [26253043] Funding Source: KAKEN

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AimThe aim of the present study was to develop a way of identifying dementia using clinical assessments made by primary care physicians under the existing medical care system in Japan. MethodsA total of 623 people aged 65years underwent standard clinical assessments by primary care physicians under the long-term-care insurance program to determine their grade of activities of daily living related to dementia. To examine the validity of the diagnosis, neuropsychiatrists carried out further diagnosis of dementia for all the participants. We regarded the dementia patients who received care for disability under the long-term care insurance program as having disabling dementia. ResultsMultivariable odds ratio (95% confidence interval) in single-grade increments of the activity was 2.1 (1.7-2.5) for dementia and 2.8 (2.2-3.4) for disabling dementia. The gradesI and IIa were near the upper-left corner in the receiver operating characteristic curves. Setting the cut-off point at gradesI or IIa yielded a higher integrated discrimination improvement, suggesting a major improvement in reducing misclassification by using these cut-off points. When we used gradesI as the cut-off point, the sensitivity (95% confidence limits) was 65% (58-72%) and the specificity was 93% (91-96%) for dementia, and the corresponding values in gradesIIa were 54% (47-62%) and 96% (94-97%). The corresponding values for disabling dementia were 83% (76-90%), 92% (90-95%), 73% (65-80%) and 96% (94-97%). ConclusionsOur findings suggest that selection of gradesI or IIa as the cut-off point would reduce instances of misclassification in the identification of dementia and disabling dementia. Geriatr Gerontol Int 2018; 18: 738-744

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