期刊
GENOMICS
卷 111, 期 3, 页码 492-499出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2018.03.008
关键词
Pseudomonas frederiksbergensis ERDD5:01; Complete genome sequence; SMRT sequencing; Cold and radiation resistance; Molecular cold adaptation; Industrial enzymes
资金
- DST, Govt. of India [DST/INSPIRE/04/2014/001280]
- Bioinformatics Infrastructure Facility (BIF) under DBT, Govt. of India
- CSIR Network Projects CeHAB [BSC0209]
- Computational Network and System Biology [MLP0076]
Pseudomonas frederiksbergensis ERDD5:01 is a psychrotrophic bacteria isolated from the glacial stream flowing from East Rathong glacier in Sikkim Himalaya. The strain showed survivability at high altitude stress conditions like freezing, frequent freeze-thaw cycles, and UV-C radiations. The complete genome of 5,746,824 bp circular chromosome and a plasmid of 371,027 bp was sequenced to understand the genetic basis of its survival strategy. Multiple copies of cold-associated genes encoding cold active chaperons, general stress response, osmotic stress, oxidative stress, membrane/cell wall alteration, carbon storage/starvation and, DNA repair mechanisms supported its survivability at extreme cold and radiations corroborating with the bacterial physiological findings. The molecular cold adaptation analysis in comparison with the genome of 15 mesophilic Pseudomonas species revealed functional insight into the strategies of cold adaptation. The genomic data also revealed the presence of industrially important enzymes.
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