期刊
GENETICS
卷 208, 期 4, 页码 1657-1669出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.117.300573
关键词
Trichophyton rubrum; Trichophyton interdigitale; dermatophyte; genome sequence; MLST; mating; recombination; LysM
资金
- National Human Genome Research Institute [U54-HG-003067]
- National Institutes of Health/National Institute of Allergy and Infectious Diseases R37 Method to Extend Research in Time [AI-39115-20]
- National Institutes of Health/National Institute of Allergy and Infectious Diseases RO1 [AI-50113-13]
- Scientific and Technological Research Council of Turkey [2219, 1059B191501539]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [12/22232-8, 13/19195-6]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/22232-8, 13/19195-6] Funding Source: FAPESP
Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum morphotype megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.
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