期刊
GENES TO CELLS
卷 23, 期 3, 页码 136-145出版社
WILEY
DOI: 10.1111/gtc.12558
关键词
amphiregulin; obese development; white adipose tissue
资金
- Grants-in-Aid for Scientific Research [15H02567] Funding Source: KAKEN
To determine adipocytokines that play a regulatory role during obesity development, we explored the genes that encode growth factors and investigated the physiological functions for adipose tissue development. Here, we isolated amphiregulin (Areg) gene whose expression was significantly up-regulated in obese adipose tissues. Areg mRNA level was positively correlated with macrophage marker gene expression in adipose tissues in vivo. Unexpectedly, Areg transgenic mice showed less adipose tissue mass with increased mRNA expression levels of Tnf- and peroxisome proliferator-activated receptor coactivator 1 (Pgc-1) and delayed white adipose tissue development during the convalescent stage in a dextran sodium sulfate-induced colitis model. This study showed that Areg mRNA expression was significantly up-regulated in obese adipose tissues and over-expression of Areg in white adipose tissue caused less adipose tissue mass.
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