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Sequential replication-coupled destruction at G1/S ensures genome stability
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CRL4Cdt2 E3 Ubiquitin Ligase and Proliferating Cell Nuclear Antigen (PCNA) Cooperate to Degrade Thymine DNA Glycosylase in S Phase
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PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase
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PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage
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MOLECULAR AND CELLULAR BIOLOGY (2012)
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment
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Checkpoint Kinase ATR Phosphorylates Cdt2, a Substrate Receptor of CRL4 Ubiquitin Ligase, and Promotes the Degradation of Cdt1 following UV Irradiation
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Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis
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GENOME BIOLOGY (2011)
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression
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Proliferating Cell Nuclear Antigen-dependent Rapid Recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged Sites after UV Irradiation in HeLa Cells
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The CRL4Cdt2 Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA
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Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron the Ubiquitin Ligase CRL4Cdt4
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MOLECULAR CELL (2009)
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TRENDS IN BIOCHEMICAL SCIENCES (2009)
CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
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Cell Division (2008)
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
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MOLECULAR CELL (2007)
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GENES & DEVELOPMENT (2007)
DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1
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EMBO REPORTS (2006)
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NATURE REVIEWS CANCER (2006)
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
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PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication
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Function and regulation of Cullin-RING ubiquitin ligases
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Phosphosite: A bioinformatics resource dedicated to physiological protein phosphorylation
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The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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