期刊
GENES & DEVELOPMENT
卷 32, 期 7-8, 页码 466-478出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.309823.117
关键词
blood-brain barrier; evolution; mouse; zebrafish
资金
- National Institutes of Health [DP1 NS092473]
- Damon Runyon Post-doctoral Fellowships
- Howard Hughes Medical Institute
The blood-brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment. Here, we describe how the BBB was initially characterized and how the current field evaluates barrier properties. We next detail the cellular nature of the BBB and discuss both the conservation and variation of BBB function across taxa. Finally, we examine our current understanding of mouse and zebrafish model systems, as we expect that comparison of the BBB across organisms will provide insight into the human BBB under normal physiological conditions and in neurological diseases.
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