期刊
GENES & DEVELOPMENT
卷 32, 期 3-4, 页码 224-229出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.306464.117
关键词
DNA replication; histone acetylation; chromatin; bromodomain; DNA replication initiation; epigenetic
资金
- National Institutes of Health National Institute of General Medical Sciences [5P20GM103636-02, 1R01GM121703]
- Oklahoma Center for the Advancement of Science and Technology
DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4. Abrogation of this interaction impairs TICRR binding to acetylated chromatin and disrupts normal S-phase progression. Our data reveal a novel function for BET proteins and establish the TICRR-BET interaction as a potential mechanism for epigenetic control of DNA replication.
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