期刊
GENES & DEVELOPMENT
卷 32, 期 1, 页码 70-78出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.309138.117
关键词
long noncoding RNAs; post-transcriptional regulation; NORAD; Pumilio; SAM68
资金
- Israeli Centers for Research Excellence [1796/12]
- Israel Science Foundation [1242/14, 1984/14]
- European Research Council project lincSAFARI
- Lapon Raymond
- Abramson Family Center for Young Scientists
- Cancer Research UK [C14303/A17043]
- University of Cambridge
- Hutchison Whampoa Ltd.
- Cancer Research UK [17043] Funding Source: researchfish
The number of known long noncoding RNA (lncRNA) functions is rapidly growing, but how those functions are encoded in their sequence and structure remains poorly understood. NORAD (noncoding RNA activated by DNA damage) is a recently characterized, abundant, and highly conserved lncRNA that is required for proper mitotic divisions in human cells. NORAD acts in the cytoplasm and antagonizes repressors from the Pumilio family that bind at least 17 sites spread through 12 repetitive units in NORAD sequence. Here we study conserved sequences in NORAD repeats, identify additional interacting partners, and characterize the interaction between NORAD and the RNA-binding protein SAM68 (KHDRBS1), which is required for NORAD function in antagonizing Pumilio. These interactions provide a paradigm for how repeated elements in a lncRNA facilitate function.
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