4.7 Article

Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramers

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

The Logic of the 26S Proteasome

Galen Andrew Collins et al.

Review Pathology

The Roles of MDM2 and MDMX in Cancer

Orit Karni-Schmidt et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

Review Biochemistry & Molecular Biology

Tetramer Formation of Tumor Suppressor Protein p53: Structure, Function, and Applications

Rui Kamada et al.

BIOPOLYMERS (2016)

Review Biochemistry & Molecular Biology

Recent advances in the structural biology of the 26S proteasome

Marc Wehmer et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Article Cell Biology

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

Alejandro Parrales et al.

NATURE CELL BIOLOGY (2016)

Article Oncology

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Patricia A. J. Muller et al.

CANCER CELL (2014)

Review Biochemistry & Molecular Biology

The cytoplasmic side of p53′s oncosuppressive activities

Anna Comel et al.

FEBS LETTERS (2014)

Article Biochemistry & Molecular Biology

The E3 Ubiquitin Protein Ligase HERC2 Modulates the Activity of Tumor Protein p53 by Regulating Its Oligomerization

Monica Cubillos-Rojas et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Constant rate of p53 tetramerization in response to DNA damage controls the p53 response

Giorgio Gaglia et al.

MOLECULAR SYSTEMS BIOLOGY (2014)

Review Oncology

Mitochondrial death functions of p53

N. D. Marchenko et al.

MOLECULAR & CELLULAR ONCOLOGY (2014)

Review Biochemistry & Molecular Biology

Regulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway

Gili Ben-Nissan et al.

BIOMOLECULES (2014)

Review Oncology

Unravelling mechanisms of p53-mediated tumour suppression

Kathryn T. Bieging et al.

NATURE REVIEWS CANCER (2014)

Article Cell Biology

Repurposing CRISPR/Cas9 for in situ functional assays

Abba Malina et al.

GENES & DEVELOPMENT (2013)

Article Medicine, Research & Experimental

Controlled Access of p53 to the Nucleus Regulates Its Proteasomal Degradation by MDM2

James R. Davis et al.

MOLECULAR PHARMACEUTICS (2013)

Review Cell Biology

p53 mutations in cancer

Patricia A. J. Muller et al.

NATURE CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Activation and control of p53 tetramerization in individual living cells

Giorgio Gaglia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Oncology

Mouse models of Mdm2 and Mdm4 and their clinical implications

Shunbin Xiong

CHINESE JOURNAL OF CANCER (2013)

Review Cell Biology

Mutant p53: one name, many proteins

William A. Freed-Pastor et al.

GENES & DEVELOPMENT (2012)

Article Biochemistry & Molecular Biology

Links between mutant p53 and genomic instability

Walter Hanel et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53

Sridharan Rajagopalan et al.

NUCLEIC ACIDS RESEARCH (2011)

Review Biochemistry & Molecular Biology

Ubiquitin-independent p53 proteasomal degradation

P. Tsvetkov et al.

CELL DEATH AND DIFFERENTIATION (2010)

Article Biochemistry & Molecular Biology

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

Roland Hjerpe et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

The Effects of Phosphomimetic Lid Mutation on the Thermostability of the N-terminal Domain of MDM2

Erin G. Worralll et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

The C terminus of p53 binds the N-terminal domain of MDM2

Masha V. Poyurovsky et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Cell Biology

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

Magali Olivier et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Biotechnology & Applied Microbiology

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

Tobias Brandt et al.

BMC GENOMICS (2009)

Review Biochemistry & Molecular Biology

Blinded by the Light: The Growing Complexity of p53

Karen H. Vousden et al.

Review Genetics & Heredity

p53 ubiquitination by Mdm2: A never ending tail?

Amanda S. Coutts et al.

DNA REPAIR (2009)

Article Biochemistry & Molecular Biology

p53 Oligomerization Is Essential for Its C-terminal Lysine Acetylation

Yoko Itahana et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Susceptibility of p53 Unstructured N Terminus to 20 S Proteasomal Degradation Programs the Stress Response

Peter Tsvetkov et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

Yan Zhu et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

Cytoplasmic functions of the tumour suppressor p53

Douglas R. Green et al.

NATURE (2009)

Article Oncology

Influence of tetramerisation on site-specific post-translational modifications of p53

Lorna J. Warnock et al.

CANCER BIOLOGY & THERAPY (2008)

Article Cell Biology

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

Tamara Terzian et al.

GENES & DEVELOPMENT (2008)

Article Biochemistry & Molecular Biology

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

Yaara Ofir-Rosenfeld et al.

MOLECULAR CELL (2008)

Article Multidisciplinary Sciences

Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2

Chen Katz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Ubiquitination and degradation of mutant p53

Natalia Lukashchuk et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation

Christopher L. Brooks et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination

Linghu Nie et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Structure-function-rescue: the diverse nature of common p53 cancer mutants

A. C. Joerger et al.

ONCOGENE (2007)

Article Cell Biology

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53

Stephanie Carter et al.

NATURE CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

Mikael S. Lindstrom et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

20S proteasomes and protein degradation by default

Gad Asher et al.

BIOESSAYS (2006)

Article Biochemistry & Molecular Biology

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

Maura Wallace et al.

MOLECULAR CELL (2006)

Review Urology & Nephrology

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

Stewart H. Lecker et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)

Article Multidisciplinary Sciences

The central region of HDM2 provides a second binding site for p53

GW Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding

S Uhrinova et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Cooperative binding of tetrameric p53 to DNA

RL Weinberg et al.

JOURNAL OF MOLECULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

MS Dai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Mono-versus polyubiquitination: Differential control of p53 fate by Mdm2

MY Li et al.

SCIENCE (2003)

Article Biochemistry & Molecular Biology

Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination

K O'Keefe et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Multidisciplinary Sciences

A peptide that binds and stabilizes p53 core domain:: Chaperone strategy for rescue of oncogenic mutants

A Friedler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Review Biochemistry & Molecular Biology

The role of tetramerization in p53 function

P Chène

ONCOGENE (2001)

Article Biochemistry & Molecular Biology

MDM2-dependent ubiquitination of nuclear and cytoplasmic P53

ZK Yu et al.

ONCOGENE (2000)

Article Multidisciplinary Sciences

Surfing the p53 network

B Vogelstein et al.

NATURE (2000)

Article Biochemistry & Molecular Biology

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

MS Rodriguez et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Article Cell Biology

The MDM2 RING-finger domain is required to promote p53 nuclear export

RK Geyer et al.

NATURE CELL BIOLOGY (2000)

Article Multidisciplinary Sciences

Rapid destruction of human Cdc25A in response to DNA damage

N Mailand et al.

SCIENCE (2000)

Article Biochemistry & Molecular Biology

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

SY Fang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)