期刊
GENE
卷 646, 期 -, 页码 47-55出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2017.11.070
关键词
Btnl5; IECs; NF-kappa B; Immune regulation; Interacting proteins
资金
- National Program on Key Basic Research Project (973 Program) [2013CB835200]
Porcine butyrophilin-like 5 (Btnl5) is a novel member of the butyrophilin family, which consists of immune regulators. The expression pattern and the function of this gene remain unclear. In this study, Btnl5 is identified as a negative regulator of the NF-kappa B pathway. Our study indicates that Btnl5 is mainly expressed in intestinal epithelial cells (IECs) and expressed in membrane systems. Btnl5 inhibits MyD88-mediated activation of the NF-kappa B pathway. Btnl5 interacts with TNF receptor-associated factor 2 (TRAF2) and transcription factor p65. Besides, Btnl5 inhibits p65-mediated activation of the NF-kappa B pathway and inhibits nuclear translocation of p65. These results suggest that Btnl5 may inhibit NF-kappa B pathway through binding and interfere nuclear translocation of p65.
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