期刊
GENE
卷 675, 期 -, 页码 36-43出版社
ELSEVIER
DOI: 10.1016/j.gene.2018.06.087
关键词
miRNA; H9c2 cells; Acute myocardial infarction; Apoptosis; Hypoxia
资金
- National Natural Science Foundation of China [31530073, 31601918, 31522055]
- Key Project of Sichuan Education Department [16ZA0025]
- Program for Innovative Research Team of Sichuan Province [2015TD0012]
- Science & Technology Support Program of Sichuan, Sichuan Province [2016NYZ0042]
- Chinese Academy of Science of Science & Technology Cooperation Project [2017JZ0025]
- Science & Technology Major Projects of Sichuan [2017NZDZX0002]
- Earmarked Fund for China Agriculture Research System [CARS-35-01A]
- District-School cooperation project from Yucheng district, Ya'an city, Sichuan Province, China (2017)
MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs involved in regulating various biological processes at the post-transcription level. Accumulating evidence suggests that hypoxia caused by acute myocardial infarction induces cardiomyocyte damage including apoptosis. Previous studies regarding the miRNAome in H9c2 cells under hypoxia have shown that hypoxia modulates miRNA expression in H9c2 cells, including miR-532-5p. We therefore investigated whether miR-532-5p has a potential function in the cardiomyocyte response to hypoxia. In the present study, we found that miR-532-5p, which was down-regulated in hypoxia-exposed H9c2 cells and the myocardium of acute myocardial infarction rats, alleviated hypoxia-induced H9c2 cell apoptosis. Additionally, we identified PDCD4 as the direct target of miR-532-5p, which partly elucidates the anti-apoptotic mechanism of miR-532-5p. In summary, this study revealed that miR-532-5p has cardioprotective effects against hypoxia-induced apoptosis in H9c2 cells.
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