期刊
GENE
卷 665, 期 -, 页码 1-5出版社
ELSEVIER
DOI: 10.1016/j.gene.2018.04.059
关键词
Circular RNA; hsa_circ_0079530; Biomarker; Oncogene; NSCLC
资金
- Zhejiang Provincial Natural Science Foundation of China [LY14H160002]
- Zhejiang Provincial Medicine and Health Science Research Foundation of China [2018234743]
Circular RNAs (circRNAs) play a crucial role in the occurrence of several diseases including cancers. However, little is known about their role in Non-small cell lung cancer (NSCLC). In the present study, we found that hsa_circ_0075930 expression levels were significantly higher in NSCLC cell lines and tissues. The elevated hsa_circ_0075930 expression was correlated with tumor size (P = 0.001) and Lymph node metastasis (P = 0.038). Functional experiments showed knockdown of hsa_circ_0075930 followed by RNA silencing restrained cell proliferation and induced cell cycle arrest of NSCLC cells. In addition, hsa_circ_0075930 suppression impaired migration and invasion potential by reversing epithelial-to-mesenchymal transition (EMT). These results indicated that hsa_circ_0075930 upregulation may be a critical oncogene and potential new biomarker in NSCLC.
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