期刊
GENE
卷 640, 期 -, 页码 79-85出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2017.10.034
关键词
miR-19; Prognosis; Acute myeloid leukemia (AML)
资金
- National Natural Science Foundation of China [81270630]
- Special Funds of Ke Jiao Qiang Wei Project of Jiangsu Province
- 333 Project of Jiangsu Province [BRA2016131]
- Six Talent Peaks Project in Jiangsu Province [2015-WSN-115]
- Medical Innovation Team of Jiangsu Province [CXTDB2017002]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX17_1821]
- China Postdoctoral Science Foundation [2016M601748]
- Social Development Foundation of Zhenjiang [SH2015058, SH2016045, SH2016046]
- Key Medical Talent Program of Zhenjiang City
Oncogenic role of miR-19 family has been identified in human cancers especially in lymphoid malignancies. However, to date, little studies investigated the role of miR-19 family in myeloid malignancies. Herein, we examined miR-19a/b expression and explored its clinical significance in de novo acute myeloid leukemia (AML). The detection of miR-19a/b expression was performed by real-time quantitative PCR in bone marrow mononuclear cells of 113 patients and 42 healthy donors. Both miR-19a/b levels were significantly increased in AML patients in contrast to controls. Patients with miR-19a/b overexpression were more frequently occurred in female, and had an older age. Moreover, cases with miR-19a overexpression had a higher frequency of U2AF1, C-KIT and CEBPA mutations, whereas miR-19b overexpressed cases harbored U2AF1 and IDH1/2 mutations. There was no significant association of miR-19a overexpression with complete remission (CR) rate and overall survival (OS) among whole-cohort AML, non-M3 AML, and cytogenetically normal AML (CN-AML). However, although miR-19b overexpression was not correlated with CR rate, patients with miR-19b overexpression presented significantly shorter OS in whole-cohort AML and a trend in non-M3 AML and CN-AML patients. Importantly, our data also showed that miR-19a/b expression level at CR phase was lower than diagnosis time, and was returned to primary level even higher when at relapse phase. Our findings revealed that miR-19a/b overexpression were frequent events in de novo AML patients. Moreover, up-regulation of miR-19b expression was associated with poor prognosis and disease recurrence in AML.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据