期刊
GENE
卷 659, 期 -, 页码 44-51出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2018.03.050
关键词
Bioengineering; MicroRNA; mRNA; CRC
资金
- National Natural Science Foundation of China (NSFC) [31371003, 81671807]
- Major State Basic Research Development Program of China (973 Program) [2013CB932902]
- Postdoctoral Science Foundation of Jiangsu Province [1501017C, 1601003C]
- 111 Project (Ministry of Education of China) [B17011]
Investigating the potential biological function of differential changed genes through integrating multiple omits data including miRNA and mRNA expression profiles, is always hot topic. However, how to evaluate the repression effect on target genes integrating miRNA and mRNA expression profiles are not fully solved. In this study, we provide an analyzing method by integrating both miRNAs and mRNAs expression data simultaneously. Difference analysis was adopted based on the repression score, then significantly repressed mRNAs were screened out by DEGseq. Pathway analysis for the significantly repressed mRNAs shows that multiple pathways such as MAPK signaling pathway, TGF-beta signaling pathway and so on, may correlated to the colorectal cancer (CRC). Focusing on the MAPK signaling pathway, a miRNA-mRNA network that centering the cell fate genes was constructed. Finally, the miRNA-mRNAs that potentially important in the CRC carcinogenesis were screened out and scored by impact index.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据