期刊
GASTROENTEROLOGY
卷 154, 期 4, 页码 820-838出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2017.11.280
关键词
Pancreatic Cancer; Stromal Remodeling; Invasion; Metastasis; Diagnostic Tool; Patient-Derived Models
资金
- National Health and Medical Research Council
- National Breast Cancer Foundation
- Cancer Institute NSW
- Australian Research Council Future Fellowship
- Len Ainsworth Pancreatic Cancer Fellowship
- Philip Hemstritch Fellowship in Pancreatic Cancer
- Avner Pancreatic Cancer Foundation
- Sydney Catalyst scholarship
- Tour de Cure
- Cancer Research UK core grant
- Cancer Research UK [22311] Funding Source: researchfish
- National Breast Cancer Foundation [IN-17-070] Funding Source: researchfish
Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment-specific therapies.
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