期刊
FUTURE ONCOLOGY
卷 14, 期 15, 页码 1443-1459出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2017-0562
关键词
cancer; glioma; PA; pilocytic astrocytoma; stachydrine
类别
Aim: Pilocytic astrocytomas (PAs) are a common adolescent malignancy. We evaluated the effects of the betaine stachydrine on human PA cells as well as its associated molecular mechanism(s). Materials & methods: Various experiments assessing stachydrine's effects on the human PA cell line Res186 were performed. Results & conclusion: Stachydrine dose-dependently suppressed proliferation and colony formation in Res186 cells with no such effect on normal astrocytes. Stachydrine downregulated CXCR4 transcription through enhancing I kappa B alpha-based NF-kappa B inhibition. Stachydrine promoted apoptosis and cyclin D1/p27(Kip1)-associated G0/G1 phase arrest in a CXCR4/ERK- and CXCR4/Akt-dependent manner. Stachydrine suppressed MMP-associated migration and invasiveness via inhibiting CXCR4/Akt/MMP-9/2 and CXCR4/ERK/MMP-9/2 pathway activity. Stachydrine inhibits the viability, migration and invasiveness of human PA cells via inhibiting CXCR4/ERK and CXCR4/Akt signaling.
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