期刊
FUTURE ONCOLOGY
卷 14, 期 3, 页码 195-203出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2017-0403
关键词
bisphosphonates; bone metastases; denosumab; multiple myeloma; RANKL; zoledronic acid
类别
Bone is a common site for malignant involvement, either as a site of metastasis, especially in breast or prostate cancer, or as a defining characteristic of the disease, as in multiple myeloma. Bone disease is a major source of morbidity, and half of patients with bone involvement develop skeletal-related events such as pathological fractures or cord compression requiring surgery and/or radiation. Skeletal involvement also increases mortality, as pathologic fractures increase the risk of dying by 20-40%. Osteoclast inhibition with bisphosphonates such as zoledronic acid and recently denosumab has been a significant improvement for bone disease. This review will focus on denosumab in the treatment of bone metastases and highlight the recent findings in multiple myeloma.
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