期刊
FUTURE ONCOLOGY
卷 14, 期 4, 页码 391-407出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2017-0255
关键词
brain metastasis; breast cancer; chemotherapy; immunotherapy; leptomeningeal disease
类别
资金
- Northwestern University Feinberg School of Medicine
Breast cancer is the most common malignancy among women and accounts for the second highest number of cancer-related deaths. With patients surviving longer due to advances in systemic control, the incidence of CNS involvement is increasing; however, the management of CNS metastases has not undergone parallel advancements. The blood-brain barrier limits the efficacy of most systemic chemotherapies, and the utilization of surgery and radiation beyond first-line therapy is limited. We will explore the recent developments in the medical management of breast cancer brain metastasis. Beyond traditional chemotherapy, we will also discuss targeted therapies and immunotherapies which may provide a survival benefit to this population and thus, offer further treatment options and a path for future research and treatment advances.
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