期刊
FUTURE MICROBIOLOGY
卷 13, 期 2, 页码 241-262出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2017-0172
关键词
antimicrobial resistance mechanisms; fungi; Gram-negative bacteria; Gram-positive bacteria; Mycobacterium tuberculosis; next-generation sequencing; whole-genome sequencing
类别
Bacteria and fungi continue to develop new ways to adapt and survive the lethal or biostatic effects of antimicrobials through myriad mechanisms. Novel antibiotic resistance genes such as lsa(C), erm(44), VCC-1, mcr-1, mcr-2, mcr-3, mcr-4, bla(KLUC-3) and bla(KLUC-4) were discovered through comparative genomics and further functional studies. As well, mutations in genes that hitherto were unknown to confer resistance to antimicrobials, such as trm, PP2C, rpsJ, HSC82, FKS2 and Rv2887, were shown by genomics and transcomplementation assays to mediate antimicrobial resistance in Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecium, Saccharomyces cerevisae, Candida glabrata and Mycobacterium tuberculosis, respectively. Thus, genomics, transcriptomics and metagenomics, coupled with functional studies are the future of antimicrobial resistance research and novel drug discovery or design.
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