期刊
FUTURE MEDICINAL CHEMISTRY
卷 10, 期 12, 页码 1497-1514出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2018-0012
关键词
alkaloids; bryostatins; marine bryozoan; macrocyclic lactones; marine natural products; new drugs discovery; secondary metabolites; sphingolipids; sterols
资金
- National Key R&D Program of China [2017YFD0201105]
- National Natural Science Foundation of China [31201551, 81473132]
- Natural Science Foundation of Shaanxi Province, China [2017JM3015]
- NATIONAL CANCER INSTITUTE [ZIABC011568] Funding Source: NIH RePORTER
Marine bryozoans play an important role for the discovery of novel bioactive compounds among marine organisms. In this review, we summarize 164 new secondary metabolites including macrocyclic lactones, sterols, alkaloids, sphingolipids and so forth from 24 marine bryozoans in the last two decades. The structural features, bioactivity, structure-activity relationship, mechanism and strategies to address the resupply of these scarce secondary metabolites are discussed. The structural and bioactive diversity of the secondary metabolites from marine bryozoans indicated the possibility of using these compounds, especially bryostatin 1 (1), bryostatin analog(BA1), alkaloids (50, 53, 127-128 and 134-139), sphingolipids sulfates (148 and 149) and sulfur-containing aromatic compound (160), as the starting points for new drug discovery.
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