期刊
FUTURE MEDICINAL CHEMISTRY
卷 10, 期 11, 页码 1319-1331出版社
FUTURE SCI LTD
DOI: 10.4155/fmc-2017-0286
关键词
NH125; Staphylococcus aureus; sub-MIC; virulence factor
资金
- NIH [P01 AI083214]
- Shanghai General Hospital Characteristic Discipline Construction Fund
- Shanghai Jiao Tong University KC Wong Medical Fellowship Fund
- China Scholarship Council (CSC) through Chinese Government Graduate Student Overseas Study Program
Aim: l-benzyl-3-cetyl-2-methylimidazolium iodide (NH125) can inhibit Staphylococcus aureus growth. We investigated the effects of sub-MIC concentrations of NH125 on S. aureus biofilm and virulence. Methodology & results: Three strains of S. aureus were tested. Sub-lethal concentrations of NH125 repressed biofilm formation. At partial sub-MICs, NH125 downregulated the expression of most virulence, while strain-dependent effects were found in the production of alpha-hemolysin, delta-hemolysin, coagulase and nuclease. In Galleria mellonella model, methicillin-resistant S. aureus pre-exposed to NH125 demonstrated significantly lower killing (p = 0.032 for 1/16 and 1/8MICs; 0.008 for 1/4MIC; and 0.001 for 1/2MIC). Conclusion: Sub-MIC concentrations of NH125 inhibited biofilm formation and virulence of S. aureus. These findings provide further support for evaluating the clinical efficacy of NH125 in staphylococcal infection.
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