期刊
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
卷 23, 期 9, 页码 906-914出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jagp.2014.09.001
关键词
Complaints; cognition; mild cognitive impairment; dementia
资金
- Australian National Health and Medical Research Council (NHMRC) [350833]
- DCRC-ABC as part of the Australian Government's Dementia Initiative
- NHMRC Project Grant seed funds [1024224]
- Dementia Collaborative Research Centre Assessment and Better Care at UNSW through the National Health and Medical Research Council as part of an Australian Government Initiative
- NHMRC capacity building grant [568940]
- NHMRC Early Career Fellowship [1053804]
Objective: There is limited understanding of the usefulness of subjective cognitive complaint(s) (SCC) in predicting longitudinal outcome because most studies focus solely on memory (as opposed to nonmemory cognitive) complaints, do not collect data from both participants and informants, do not control for relevant covariates, and have limited outcome measures. Therefore the authors investigate the usefulness of participant and informant SCCs in predicting change in cognition, functional abilities, and diagnostic classification of mild cognitive impairment or dementia in a community-dwelling sample over 4 years. Methods: Nondemented participants (N = 620) in the Sydney Memory and Ageing Study aged between 70 and 90 years completed 15 memory and 9 nonmemory SCC questions. An informant completed a baseline questionnaire that included 15 memory and 4 nonmemory SCC questions relating to the participant. Neuropsychological, functional, and diagnostic assessments were carried out at baseline and again at 4-year follow-up. Cross-sectional and longitudinal analyses were carried out to determine the association between SCC indices and neuropsychological, functional, and diagnostic data while controlling for psychological measures. Results: Once participant characteristics were controlled for, participant complaints were generally not predictive of cognitive or functional decline, although participant memory-specific complaints were predictive of diagnostic conversion. Informant-related memory questions were associated with global cognitive and functional decline and with diagnostic conversion over 4 years. Conclusion: Informant memory complaint questions were better than participant complaints in predicting cognitive and functional decline as well as diagnoses over 4 years.
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