期刊
FUTURE ONCOLOGY
卷 11, 期 16, 页码 2351-2363出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.15.101
关键词
angiogenesis; cancer hallmarks; cancer therapy; immune regulator; miRNA
类别
资金
- Major Research Plan of the National Natural Science Foundation of China [91229110]
- National Science Foundation of China [81273215]
- Specialized Research Fund for the Doctoral Program of Higher Education [20120071110046]
- Science and Technology Commission of Shanghai Municipality [13JC1407700]
Since their first discovery in chronic lymphocytic leukemia, miR-15a and miR-16 have been reported to act as tumor suppressors or potential oncomiRs in different types of cancer. This review summarizes the history, biological properties and the important functions of these two miRNAs in cancer. It also introduces their roles as regulators of immune responses and angiogenesis, endogenous controls as well as potential targets and hallmarks of cancer.
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