期刊
FUTURE ONCOLOGY
卷 11, 期 3, 页码 511-524出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.14.238
关键词
biomarker panels; brain tumors; circulating biomarkers; proteomics; targeted therapy
类别
资金
- Sectorial Operational Programme Human Resources Development (SOPHRD) - European Social Fund
- Romanian Government [POSDRU 141531]
- [PN 09.33-04.15]
- [PN 09.33-03.10]
- [PN 09.33-01.01]
An important goal of oncology is the development of cancer risk-identifier biomarkers that aid early detection and target therapy. High-throughput profiling represents a major concern for cancer research, including brain tumors. A promising approach for efficacious monitoring of disease progression and therapy could be circulating biomarker panels using molecular proteomic patterns. Tailoring treatment by targeting specific protein-protein interactions and signaling networks, microRNA and cancer stem cell signaling in accordance with tumor phenotype or patient clustering based on biomarker panels represents the future of personalized medicine for brain tumors. Gathering current data regarding biomarker candidates, we address the major challenges surrounding the biomarker field of this devastating tumor type, exploring potential perspectives for the development of more effective predictive biomarker panels.
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