期刊
FUTURE ONCOLOGY
卷 11, 期 4, 页码 675-689出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.14.254
关键词
cancer immunotherapy; oncolytic virus
类别
资金
- Canadian Cancer Society
- Cancer Research Society
- Canadian Cancer Society Research Institute
Despite huge economic and intellectual investments, developing effective cancer treatments continues to be an overarching challenge. Engineered oncolytic viruses (OVs) present self-amplifying immunotherapy platforms capable of preferential cytotoxicity to cancer cells and simultaneous activation of host anti-tumor immunity. In preclinical studies, OVs are showing potent therapeutic effects when used in combination with other immune therapy strategies. In the clinic, the immunotherapeutic effects of OVs are showing promising results. Here we review current strategies for engineering OVs, and present a perspective of future directions within a discussion of the current outcomes of combinatorial approaches with other cancer immunotherapy platforms.
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