期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 23, 期 -, 页码 1680-1686出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4666
关键词
LINE-1 Retrotransposon; Cancer Biology; Experimental Evidence; Review
资金
- Department of Pathology, Immunology, and Laboratory Medicine at the University of Florida
LINE-1 retrotransposons are ubiquitous genetic elements interspersed within the primary nuclear genome of modern day humans. Although shorter LINE-1-derived sequences occupy nearly onein-five nucleotides of our genome, we are just beginning to appreciate the link between these important genetic elements and cancer, perhaps the most well-studied major degenerative disorder affecting humanity today. Herein, I summarize empirical observations linking LINE-1 to tumorigenesis. The work is organized into three major parts. First, I provide an overview of LINE-1 activity in cancer; highlighting major features of LINE-1 life-cycle such as: promoter methylation, transcription, translation, and retrotransposition. Second, I discuss three genetic pathways - epigenetic regulation, interferon signaling, and genome integrity-as they relate to LINE-1 regulation in cancer. Finally, I review most recent body of work linking LINE-1 as not only a diagnostic cancer biomarker, but also a potential therapeutic target.
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