期刊
FUTURE MICROBIOLOGY
卷 10, 期 10, 页码 1553-1578出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb.15.90
关键词
anti-CSP; anti-HBs; AS01; AS02; geometric mean concentration; immune responses; RTS; S; AS; vaccine efficacy
类别
The first clinical Phase III trial evaluating a malaria vaccine was completed in December 2013 at 11 sites from seven sub-Saharan African countries. This systematic review assesses data of Phase I-III trials including malaria-naive adults and adults, children and infants from malaria endemic settings in sub-Saharan Africa. The main endpoint of this systematic review was an analysis of the consistency of efficacy and immunogenicity data from respective Phase I-III trials. In addition, safety data from a pooled analysis of RTS/AS Phase II trials and RTS,S/AS01 Phase III trial were reviewed. The RTS,S/AS01 malaria vaccine may become available on the market in the coming year. If so, further strategies should address challenges on how to optimize vaccine efficacy and implementation of RTS,S/AS01 vaccine within the framework of established malaria control measures.
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