期刊
FUTURE MEDICINAL CHEMISTRY
卷 7, 期 4, 页码 493-512出版社
FUTURE SCI LTD
DOI: 10.4155/FMC.15.6
关键词
-
资金
- NSF [CBET 1264509]
- Camille Dreyfus Foundation
- Kraybill biochemistry fellowship
Biofilms are communities of microorganisms that are attached to a surface and play a significant role in the persistence of bacterial infections. Bacteria within a biofilm are several orders of magnitude more resistant to antibiotics, compared with planktonic bacteria. Thus far, no drugs are in clinical use that specifically target bacterial biofilms. This is probably because until recently the molecular details of biofilm formation were poorly understood. Bacteria integrate information from the environment, such as quorum-sensing autoinducers and nutrients, into appropriate biofilm-related gene expression, and the identity of the key players, such as cyclic dinucleotide second messengers and regulatory RNAs are beginning to be uncovered. Herein, we highlight the current understanding of the processes that lead to biofilm formation in many bacteria.
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