期刊
FUTURE MEDICINAL CHEMISTRY
卷 7, 期 13, 页码 1809-1828出版社
FUTURE SCI LTD
DOI: 10.4155/fmc.15.105
关键词
-
资金
- French Ministere de l'Education Nationale, de l'Enseignement Superieur et de la Recherche
- LabEx SYNORG [ANR-11-LABX-0029]
Nucleoside analogs are extremely useful for the development of therapeutic agents to control viral diseases and cancer. Among the numerous modifications on the nucleoside skeleton, replacement of the oxygen of the furanose ring by a CH2 group resulted in increased flexibility and higher resistance to phosphorylases and led to carbocyclic nucleoside analogs (or carbanucleosides). The broad spectrum of biological activities of carbocyclic nucleosides led to tremendous research interest in their syntheses. The article documents recent strategies for the synthesis of active carbocyclic nucleosides by presenting individual case studies, such as the neplanocins, entecavir and selected fluorinated carbocyclic nucleosides. Furthermore, it provides new insights into new directions for more potent and active carbocyclic nucleoside analogs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据