期刊
FOOD RESEARCH INTERNATIONAL
卷 111, 期 -, 页码 351-360出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.foodres.2018.05.038
关键词
Chitosan; Nanoparticles; Catechin; Quercetin; Antioxidant; Antibacterial
资金
- National Natural Science Foundation of China [31571836, 31201417]
- Shandong Agricultural Innovation Team [SDAIT-24-05]
- Shandong Double Tops Program [SYT2017XTTD04]
A novel chitosan-based nanoparticle (G-C-Q NPs), which simultaneously loaded catechin and quercetin, was synthesized through ionic gelation reaction between chitosan and sodium tripolyphosphate and subsequent modification by genipin. Chemical structure, size distribution, morphology, entrapment efficiency, in vitro release behavior, antioxidant and antibacterial effects of G-C-Q NPs were investigated. Results showed that G-C-Q NPs were dispersed as an ellipsoidal shape with an average diameter of 180.4 nm and a zeta potential of 31.79 +/- 1.28 mV. Entrapment efficiency of catechin and quercetin reached 76.35 +/- 1.37% and 52.23 +/- 2.45%, respectively. In vitro release study showed that both catechin and quercetin had a sustainable release from the G-C-Q NPs. G-C-Q NPs had higher or comparable potency in scavenging DPPH, ABTS center dot (+), center dot OH and O-2 center dot(-) radicals and in suppressing growing of Escherichia coli, Bacillus subtilis Staphylococcus aureus as compared to native drugs (single or combination). These results contribute some basis to the design and fabrication of polymeric nanoparticle delivery systems for multiple bioactive compounds with beneficial properties.
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