相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Empirical Estimation of Local Dielectric Constants: Toward Atomistic Design of Collagen Mimetic Peptides
Douglas H. Pike et al.
BIOPOLYMERS (2015)
PepT1, ASBT-Linked Prodrug Strategy to Improve Oral Bioavailability and Tissue Targeting Distribution
Xiaopeng Han et al.
CURRENT DRUG METABOLISM (2015)
Construction and screening of vast libraries of natural product-like macrocyclic peptides using in vitro display technologies
Nasir K. Bashiruddin et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2015)
Peptide therapeutics: current status and future directions
Keld Fosgerau et al.
DRUG DISCOVERY TODAY (2015)
Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability
Conan K. Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Peptide therapeutics: Targeting the undruggable space
Natia Tsomaia
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products
Andrew T. Bockus et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Rational Design of Dual Peptides Targeting Ghrelin and Y2 Receptors to Regulate Food Intake and Body Weight
Tom-Marten Kilian et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products
William M. Hewitt et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Recent Development of Peptide Drugs and Advance on Theory and Methodology of Peptide Inhibitor Design
Qi-Shi Du et al.
MEDICINAL CHEMISTRY (2015)
Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
Martin P. Barr et al.
MOLECULAR CANCER (2015)
GalaxyPepDock: a protein-peptide docking tool based on interaction similarity and energy optimization
Hasup Lee et al.
NUCLEIC ACIDS RESEARCH (2015)
CABS-dock web server for the flexible docking of peptides to proteins without prior knowledge of the binding site
Mateusz Kurcinski et al.
NUCLEIC ACIDS RESEARCH (2015)
AnchorDock: Blind and Flexible Anchor-Driven Peptide Docking
Avraham Ben-Shimon et al.
STRUCTURE (2015)
Machine Learning Assisted Design of Highly Active Peptides for Drug Discovery
Sebastien Giguere et al.
PLOS COMPUTATIONAL BIOLOGY (2015)
Bond distances in polypeptide backbones depend on the local conformation
Roberto Improta et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2015)
Novel expression of Neuropilin 1 on human tumor-infiltrating lymphocytes in colorectal cancer liver metastases
Belal Chaudhary et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2015)
Predicting Peptide Binding Sites on Protein Surfaces by Clustering Chemical Interactions
Chengfei Yan et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2015)
New Compstatin Peptides Containing N-Terminal Extensions and Non-Natural Amino Acids Exhibit Potent Complement Inhibition and Improved Solubility Characteristics
Ronald D. Gorham et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Tumor-Penetrating iRGD Peptide Inhibits Metastasis
Kazuki N. Sugahara et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel
Zongyun Chen et al.
SCIENTIFIC REPORTS (2015)
Molecular Grafting onto a Stable Framework Yields Novel Cyclic Peptides for the Treatment of Multiple Sclerosis
Conan K. Wang et al.
ACS CHEMICAL BIOLOGY (2014)
Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable
Daniel S. Nielsen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
A Specific STAT3-Binding Peptide Exerts Antiproliferative Effects and Antitumor Activity by Inhibiting STAT3 Phosphorylation and Signaling
Daejin Kim et al.
CANCER RESEARCH (2014)
Modulation, Bioinformatic Screening, and Assessment of Small Molecular Peptides Targeting the Vascular Endothelial Growth Factor Receptor
Shibin Feng et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2014)
Derivation of ligands for the complement C3a receptor from the C-terminus of C5a
Reena Halai et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties
Michel Demeule et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)
Erica M. Haslach et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A
Andreas O. Frank et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress
Loren D. Walensky et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Combination of Amino Acid/Dipeptide with Nitric Oxide Donating Oleanolic Acid Derivatives as PepT1 Targeting Antitumor Prodrugs
Lei Fang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Transferrin Receptor-Mediated Endocytosis: A Useful Target for Cancer Therapy
Stephanie Tortorella et al.
JOURNAL OF MEMBRANE BIOLOGY (2014)
Anaphylaxis and Hypotension after Administration of Peginesatide
Charles L. Bennett et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
PEP-SiteFinder: a tool for the blind identification of peptide binding sites on protein surfaces
Adrien Saladin et al.
NUCLEIC ACIDS RESEARCH (2014)
De Novo Peptide Design and Experimental Validation of Histone Methyltransferase Inhibitors (vol 9, e90095, 2014)
J. Smadbeck et al.
PLOS ONE (2014)
PaFlexPepDock: Parallel Ab-Initio Docking of Peptides onto Their Receptors with Full Flexibility Based on Rosetta
Haiou Li et al.
PLOS ONE (2014)
Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients
Conan K. Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Two-level QSAR network (2L-QSAR) for peptide inhibitor design based on amino acid properties and sequence positions
Q. S. Du et al.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2014)
An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability
Hong-Bo Pang et al.
NATURE COMMUNICATIONS (2014)
Serum Stable Natural Peptides Designed by mRNA Display
Shannon M. Howell et al.
SCIENTIFIC REPORTS (2014)
A Rationally Engineered Anti-HIV Peptide Fusion Inhibitor with Greatly Reduced Immunogenicity
Frances Brauer et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Conformational investigation of antibiotic proximicin by X-ray structure analysis and quantum studies suggest a stretched conformation of this type of γ-peptide
Alexander Denisiuk et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Cyclotides as Grafting Frameworks for Protein Engineering and Drug Design Applications
Aaron G. Poth et al.
BIOPOLYMERS (2013)
De Novo Design of a Tumor-Penetrating Peptide
Luca Alberici et al.
CANCER RESEARCH (2013)
Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1
Susan Clardy-James et al.
CHEMMEDCHEM (2013)
A Brief Overview of Antimicrobial Peptides Containing Unnatural Amino Acids and Ligand-Based Approaches for Peptide Ligands
Jayendra B. Bhonsle et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)
Future directions for peptide therapeutics development
Allan A. Kaspar et al.
DRUG DISCOVERY TODAY (2013)
Development of an Informatics Platform for Therapeutic Protein and Peptide Analytics
Mark R. Hansen et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2013)
Constrained H-Phe-Phe-NH2 Analogues with High Affinity to the Substance P 1-7 Binding Site and with Improved Metabolic Stability and Cell Permeability
Rebecca Fransson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates
Kathryn R. Heard et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Screening Bicyclic Peptide Libraries for Protein-Protein Interaction Inhibitors: Discovery of a Tumor Necrosis Factor-α Antagonist
Wenlong Lian et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
A Unified Conformational Selection and Induced Fit Approach to Protein-Peptide Docking
Mikael Trellet et al.
PLOS ONE (2013)
Targeting Caspase-3 as Dual Therapeutic Benefits by RNAi Facilitating Brain-Targeted Nanoparticles in a Rat Model of Parkinson's Disease
Yang Liu et al.
PLOS ONE (2013)
Phage selection of cyclic peptide antagonists with increased stability toward intestinal proteases
Vanessa Baeriswyl et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2013)
Protein-Peptide Complex Prediction through Fragment Interaction Patterns
Erik Verschueren et al.
STRUCTURE (2013)
Exploring Protein-Peptide Binding Specificity through Computational Peptide Screening
Arnab Bhattacherjee et al.
PLOS COMPUTATIONAL BIOLOGY (2013)
PepBind: A Comprehensive Database and Computational Tool for Analysis of Protein–peptide Interactions
Arindam Atanu Das et al.
GENOMICS PROTEOMICS & BIOINFORMATICS (2013)
Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment
Clarence T. T. Wong et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
In Silico and in Vitro Elucidation of BH3 Binding Specificity toward Bcl-2
Nir London et al.
BIOCHEMISTRY (2012)
Protease-resistant peptide designuempowering nature's fragile warriors against HIV
Matthew T. Weinstock et al.
BIOPOLYMERS (2012)
Brainpeps: the blood-brain barrier peptide database
Sylvia Van Dorpe et al.
BRAIN STRUCTURE & FUNCTION (2012)
Peptide Bicycles that Inhibit the Grb2 SH2 Domain
Justin S. Quartararo et al.
CHEMBIOCHEM (2012)
Influence of an Unnatural Amino Acid Side Chain on the Conformational Dynamics of Peptides
Chen Han et al.
CHEMPHYSCHEM (2012)
Recent work in the development and application of protein-peptide docking
Joseph Audie et al.
FUTURE MEDICINAL CHEMISTRY (2012)
De Novo Peptide Design with C3a Receptor Agonist and Antagonist Activities: Theoretical Predictions and Experimental Validation
Meghan L. Bellows-Peterson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Predicting and Improving the Membrane Permeability of Peptidic Small Molecules
Salma B. Rafi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
In silico predictions of 3D structures of linear and cyclic peptides with natural and non-proteinogenic residues
Jerome Beaufays et al.
JOURNAL OF PEPTIDE SCIENCE (2012)
PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides
Pierre Thevenet et al.
NUCLEIC ACIDS RESEARCH (2012)
Transtumoral targeting enabled by a novel neuropilin-binding peptide
L. Roth et al.
ONCOGENE (2012)
TumorHoPe: A Database of Tumor Homing Peptides
Pallavi Kapoor et al.
PLOS ONE (2012)
Computer-aided antibody design
Daisuke Kuroda et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2012)
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
Arthur C. Rand et al.
MEDCHEMCOMM (2012)
Computational Design of a PDZ Domain Peptide Inhibitor that Rescues CFTR Activity
Kyle E. Roberts et al.
PLOS COMPUTATIONAL BIOLOGY (2012)
Drug-permeability and transporter assays in Caco-2 and MDCK cell lines
Donna A. Volpe
FUTURE MEDICINAL CHEMISTRY (2011)
Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma
Fernanda I. Staquicini et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Targeted brain delivery of itraconazole via RVG29 anchored nanoparticles
Wei Chen et al.
JOURNAL OF DRUG TARGETING (2011)
Novel Peptide-Specific Quantitative Structure-Activity Relationship (QSAR) Analysis Applied to Collagen IV Peptides with Antiangiogenic Activity
Corban G. Rivera et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Backbone Cyclic Peptide Inhibitors of Protein Kinase B (PKB/Akt)
Yftah Tal-Gan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Oral Delivery of the Appetite Suppressing Peptide hPYY(3-36) through the Vitamin B12 Uptake Pathway
Christopher H. Fazen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Elucidation of the Contribution of Active Site and Exosite Interactions to Affinity and Specificity of Peptidylic Serine Protease Inhibitors Using Non-Natural Arginine Analogs
Masood Hosseini et al.
MOLECULAR PHARMACOLOGY (2011)
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Lydia Alvarez-Erviti et al.
NATURE BIOTECHNOLOGY (2011)
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
Tina R. White et al.
NATURE CHEMICAL BIOLOGY (2011)
Rosetta FlexPepDock web server-high resolution modeling of peptide-protein interactions
Nir London et al.
NUCLEIC ACIDS RESEARCH (2011)
Four Small Puzzles That Rosetta Doesn't Solve
Rhiju Das
PLOS ONE (2011)
Rosetta FlexPepDockab-initio: Simultaneous Folding, Docking and Refinement of Peptides onto Their Receptors
Barak Raveh et al.
PLOS ONE (2011)
How Fast-Folding Proteins Fold
Kresten Lindorff-Larsen et al.
SCIENCE (2011)
Discovery of Entry Inhibitors for HIV-1 via a New De Novo Protein Design Framework
M. L. Bellows et al.
BIOPHYSICAL JOURNAL (2010)
Cyclotides, A Promising Molecular Scaffold for Peptide-Based Therapeutics
Krishnappa Jagadish et al.
BIOPOLYMERS (2010)
Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
Jason Phan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
PepX: a structural database of non-redundant protein-peptide complexes
Peter Vanhee et al.
NUCLEIC ACIDS RESEARCH (2010)
VitAL: Viterbi Algorithm for de novo Peptide Design
E. Besray Unal et al.
PLOS ONE (2010)
Discovery of High-Affinity Protein Binding Ligands - Backwards
Chris W. Diehnelt et al.
PLOS ONE (2010)
Serum Stabilities of Short Tryptophan-and Arginine-Rich Antimicrobial Peptide Analogs
Leonard T. Nguyen et al.
PLOS ONE (2010)
Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs
Kazuki N. Sugahara et al.
SCIENCE (2010)
The Structural Basis of Peptide-Protein Binding Strategies
Nir London et al.
STRUCTURE (2010)
Long-timescale molecular dynamics simulations of protein structure and function
John L. Klepeis et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)
Creating Protein Affinity Reagents by Combining Peptide Ligands on Synthetic DNA Scaffolds
Berea A. R. Williams et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Physiochemical drug properties associated with in vivo toxicological outcomes
Jason D. Hughes et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Toward full-sequence de novo protein design with flexible templates for human beta-defensin-2
Ho Ki Fung et al.
BIOPHYSICAL JOURNAL (2008)
Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2
A. Regina et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Recent advances in QSAR and their applications in predicting the activities of chemical molecules, peptides and proteins for drug design
Qi-Shi Du et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2008)
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity
Shmuel Hess et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Identification and design of peptides as a new drug delivery system for the brain
Michel Demeule et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Predicting the affinity of epitope-peptides with class I MHC molecule HLA-A*0201: an application of amino acid-based peptide prediction
Qi-Shi Du et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2007)
Transvascular delivery of small interfering RNA to the central nervous system
Priti Kumar et al.
NATURE (2007)
Quantitative comparison of the relative cell permeability of cyclic and linear peptides
Yong-Uk Kwon et al.
CHEMISTRY & BIOLOGY (2007)
Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: Successful in silico prediction of the relative permeabilities of cyclic peptides
Taha Rezai et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers
T Rezai et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity
M Koolpe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability
R Ano et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, Nα-amidino-Tyr-D-Arg-Phe-MeβAla-OH (ADAMB)
T Ogawa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Transferrin and transferrin receptor function in brain barrier systems
T Moos et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2000)
分享论文
